NSF PAR Search | NSF Public Access Repository

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

Combining Chemical Catalysis with Enzymatic Steps for the Synthesis of the Artemisinin Precursor Dihydroartemisinic Acid

https://doi.org/10.1021/acssynbio.4c00707

Upadhyay, Vikas; Li, Hongxiang; He, Jiachen; Ocampo, Blake Edward; Cook, Silas; Zhao, Huimin; Maranas, Costas D (April 2025, ACS Synthetic Biology)

Free, publicly-accessible full text available April 18, 2026
Directed Ni-Catalyzed Reductive Arylation of Aliphatic C–H Bonds

https://doi.org/10.1021/acs.orglett.2c00447

Liu, Zhi-Yun; Cook, Silas P. (May 2022, Organic Letters)

Full Text Available
Mechanistic Insight into Cu-Catalyzed C–N Coupling of Hindered Aryl Iodides and Anilines Using a Pyrrol-ol Ligand Enables Development of Mild and Homogeneous Reaction Conditions

https://doi.org/10.1021/acscatal.2c06201

de Gombert, Antoine; Darù, Andrea; Ahmed, Tonia S.; Haibach, Michael C.; Li-Matsuura, Rei; Yang, Cassie; Henry, Rodger F.; Cook, Silas P.; Shekhar, Shashank; Blackmond, Donna G. (March 2023, ACS Catalysis)

Full Text Available
Synthesis of Tetrahydroisoquinolines Through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination

https://doi.org/10.1021/acs.orglett.9b02353

Marcyk, Paul T.; Cook, Silas P. (August 2019, Organic Letters)

Full Text Available
Copper-Catalyzed, N-Directed Csp ³ –H Trifluoromethylthiolation (−SCF ₃ ) and Trifluoromethylselenation (−SeCF ₃ )

https://doi.org/10.1021/jacs.9b10316

Modak, Atanu; Pinter, Emily N.; Cook, Silas P. (October 2019, Journal of the American Chemical Society)

Full Text Available
N-Directed fluorination of unactivated Csp ³ –H bonds

https://doi.org/10.1039/C9SC04055B

Pinter, Emily N.; Bingham, Jenna E.; AbuSalim, Deyaa I.; Cook, Silas P. (January 2020, Chemical Science)

Site-selective fluorination of aliphatic C–H bonds remains synthetically challenging. While directed C–H fluorination represents the most promising approach, the limited work conducted to date has enabled just a few functional groups as the arbiters of direction. Leveraging insights gained from both computations and experimentation, we enabled the use of the ubiquitous amine functional group as a handle for the directed C–H fluorination of Csp 3 –H bonds. By converting primary amines to adamantoyl-based fluoroamides, site-selective C–H fluorination proceeds under the influence of a simple iron catalyst in 20 minutes. Computational studies revealed a unique reaction coordinate for the catalytic process and offer an explanation for the high site selectivity.
more » « less
Full Text Available
Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes

https://doi.org/10.1021/acs.orglett.9b00427

Marcyk, Paul T.; Cook, Silas P. (March 2019, Organic Letters)

Full Text Available
Aqueous Benzylic C–H Trifluoromethylation for Late-Stage Functionalization

https://doi.org/10.1021/jacs.8b08547

Guo, Shuo; AbuSalim, Deyaa I.; Cook, Silas P. (September 2018, Journal of the American Chemical Society)

Full Text Available

Search for: All records